• 姓名: 胡国庆
  • 性别: 男
  • 职称: 研究员、博士生导师
  • 学历: 博士
  • 电话: (0086)-10-82544298
  • 传真: (0086)-10-82543977
  • 电子邮件: guoqing.hu@imech.ac.cn
  • 通讯地址 北京北四环西路15号,中国科学院力学研究所

    简历:

  •  

    研究领域:

  • 微纳米流体力学、生物分子/颗粒/细胞/液滴输运及操控、微纳流控器件设计、颗粒与肺部交互作用

    招聘博士后,力学、工程热、物理、应用数学、化工等专业均可,欢迎联系

     

    社会任职:

  • 中国力学学会副秘书长、中国力学学会流体力学专业委员会委员、中国力学学会“微纳尺度流动”专业组组长、北京力学会常务理事、北京力学会流体力学专委会主任

    Acta Mechanica Sinica编委、Scientific Reports编委

    获奖及荣誉:

  •  

    代表论著:

  • 期刊论文

    67. Wang, X.; Wang, X,; Bai, X.; Yan, L.; Liu, T.; Wang, M.; Song, Y.; Hu, G.; Gu, Z.; Miao, Q. & Chen, C. Nanoparticle ligand exchange and its effects at the nanoparticle-cell membrane interface. Nano Letters, doi: 10.1021/acs.nanolett.8b02638 (2018)

    66. Shi, L.; Li, Y.; Meng, Y., Hu, G. & Tian, Y. Fluid property effects on the splashing in teapot effect. The Journal of Physical Chemistry C, 122, 21411-21417 (2018)

    65. Bai, X.; Xu, M.; Liu, S. & Hu, G. Computational investigations of the interaction between the cell membrane and nanoparticles coated with a pulmonary surfactant. ACS Applied Materials & Interfaces, 10, 20368-20376 (2018)

    64. Wang, Y.; Chen, X.; Sun, K.; Li, K.; Zhang, F.; Dai, B.; Shen, J.; Hu, G. & Wang, S. Directional transport of centimeter-scale object on anisotropic microcilia surface under water. Science China Materials, 1, 1-9 (2018)

    63. Su, J.; Chen, X. & Hu, G. Inertial migrations of cylindrical particles in rectangular microchannels: Variations of equilibrium positions and equivalent diameters. Physics of Fluids, 30, 032007 (2018, Editor's Pick)

    62. Wang, J.; Yang, Y.; Yu, M.; Hu, G.; Gan, Y.; Gao, H. & Shi, X. Diffusion of rod-like nanoparticles in non-adheve and adhesive porous polymeric gels. Journal of the Mechanics and Physics of Solids, 112, 431-457 (2018)

    61. Liu, Y.; Chen, X.; Liu, S. & Hu, G. Quantitative assessments of mechanical responses upon radial extracorporeal shock wave therapy. Advanced Science, 3, 1870015 (2018, Frontispiece)

    60. Luo, Z.; Li, S.; Xu, Y.; Ren, H.; Zhang, X.; Hu, G.; Huang, F. & Yue, T. Extracting pulmonary surfactants to form inverse micelles on suspended graphene nanosheets. Environmental Science: Nano, 5, 130-140 (2018)

    59. Zhang, T.; Wang, Y.; Zhang, F.; Chen, X.; Hu, G.; Meng, J. & Wang, S. Bio-inspired superhydrophilic coatings with high anti-adhesion against mineral scales. NPG Asia Materials, 10, e471 (2018)

    58. Kale, A.; Song, L.; Lu, X.; Yu, L.; Hu, G. & Xuan, X. Electrothermal enrichment of submicron particles in an insulator-based dielectrophoretic microdevice. Electrophoresis, doi: 10.1002/elps.201700342 (2017)

    57. Shi, L.; Liu, Y.; Lu, H.; Meng, Y.; Hu, G. & Tian, Y. Viscous force retards initial droplet spreading. Journal of Physical Chemistry C, 121, 22054-22059 (2017)

    56. Tian, F.; Zhang, W.; Cai, L.; Li, S.; Hu, G.; Cong, Y.; Liu, C.; Li, T. & Sun, J. Microfluidic co-flow of Newtonian and viscoelastic fluids for high-resolution separation of microparticles. Lab on a Chip, 17, 3078-3085 (2017)

    55. Liu, C.; Guo, J.; Tian, F.; Yang, N.; Yan, F.; Ding, Y.; Wei, J.; Hu, G.; Nie, G. & Sun, J. Field-free isolation of exosomes from extracellular vesicles by microfluidic viscoelastic flows. ACS Nano, 11, 6968-6976 (2017) 

    54. Chen, X.; Sun, Y.; Xue, C.; Yu, Y. & Hu, G. Tunable structures of compound droplets formed by collision of immiscible microdroplets. Microfluidics and Nanofluidics, 21, 109 (2017)

    53. Hu, Q.; Bai, X.; Hu, G. & Zuo, Y. Y. Unveiling the molecular structure of pulmonary surfactant corona on nanoparticles. ACS Nano, 11, 6832-6842 (2017)

    52. Prabhakaran, R. A.; Zhou, Y.; Zhao, C.; Hu, G.; Song, Y.; Wang, J.; Yang, C. & Xuan, X. Induced charge effects on electrokinetic entry flow. Physics of Fluids, 29, 062001 (2017)

    51. Lu, X.; Liu, C.; Hu, G. & Xuan, X. Particle manipulations in non-Newtonian microfluidics: A review. Journal of Colloid and Interface Science, 500, 182 (2017)

    50. Liu, C.; Hu, G. High-throughput particle manipulation based on hydrodynamic effects in microchannels. Micromachines, 8(3), 73 (2017, Invited Perspective)

    49. Prabhakaran, R.A.; Zhou, Y.; Kale, A.; Song, Y.; Hu, G. & Xuan, X. Joule heating effects on electroosmotic entry flow. Electrophoresis, 38(5), 572-579 (2017) 

    48. Liu, C.; Ding, B.; Xue, C.; Tian, Y.; Hu, G. & Sun, J. Sheathless focusing and separation of diverse nanoparticles in viscoelastic solutions with minimized shear thinning. Analytical Chemistry, 88(24), 12547-12553 (2016)  

    47. Zhang, L.; Sun, J.; Wang, Y.; Wang, J.; Shi, X. & Hu, G. A non-specific organelle-targeting strategy with core-shell nanoparticles of varied lipid components/ratios. Analytical Chemistry, 88(14), 7344-7351 (2016)

    46. Xue, C.; Chen, X.; Liu, C. & Hu, G. Lateral migration of dual droplet trains in a double spiral microchannel. Science China Physics, Mechanics & Astronomy, 59(7), 1-10 (2016)

    45. Xue, C.; Zheng, X.; Chen, K.; Tian, Y. & Hu, G. Probing non-Gaussianity in confined diffusion of nanoparticles. The Journal of Physical Chemistry Letters, 7, 514-519 (2016)

    44. Liu, C.; Xue, C.; Sun, J. & Hu, G. A generalized formula for inertial lift on a sphere in microchannels. Lab on a Chip, 16, 884-892 (2016)

    43. Hu, Q.; Jiao, B.; Shi, X.; Valle, R.; Zuo, Y. & Hu, G. Effects of graphene oxide nanosheets on ultrastructure and biophysical properties of pulmonary surfactant film. Nanoscale, 7, 18025-18029 (2015) 

    42. Song, K., Hu, G., Hu X., Zhong, R. & Lin, B. Encoding and controlling of two droplet trains in a microfluidic network with the loop-like structure. Microfluidics and Nanofluidics, 19, 1363-1375 (2015) 

    41. Qian, Y., Zhang, J., Hu, Q., Xu, M., Chen, Y., Hu, G., Zhao, M. & Liu, S. Silver nanoparticles-induced hemoglobin decrease alteration of histone 3 methylation status. Biomaterials, 70, 12-22 (2015)  

    40. Chen, X., Song, Y., Li, D. & Hu, G. Deformation and interaction of droplet pairs in a microchannel under ac electric fields. Physical Review Applied, 4, 024005 (2015) 

    39. Feng, Q., Zhang, L., Liu, C., Li, X., Hu, G., Sun, J. & Jiang, X. Microfluidic based high throughut synthesis of lipid-polymer hybrid nanoparticles with tunable diameters. Biomicrofluidics, 9, 052604 (2015) 

    38. Liu, C., Xue, C., Chen, X., Shan, L., Tian, Y. & Hu, G. Size-based separation of particles and cells utilizing viscoelastic effects in straight microchannels. Analytical Chemistry, 87, 6041-6048 (2015) 

    37. Chen, K., Shan, L., He, S., Hu, G., Meng, Y. & Tian, Y. Biphasic resistive pulses and ion concentration modulation during particle translocation through cylindrical nanopores. Journal of Physical Chemistry C, 119, 8329-8335 (2015)   

    36. 陈晓东,胡国庆. 微流控器件中的多相流动力学进展, 201503 (2015)  

    35. Liu, C., Hu, G., Jiang, X. & Sun, J. Inertial focusing of spherical particles in rectangular microchannels over a wide range of Reynolds numbers. Lab on a Chip, 15, 1168-1177 (2015)  

    34. Chen, X., Xue, C., Zhang, L., Hu, G., Jiang, X. & Sun, J. Inertial migration of deformable droplets in a microchannel. Physics of Fluids, 26, 112003 (2014) 

    33. Wang, J., Zhang, L., Xue, J. & Hu, G. Ion diffussion coefficient measurements in nanochannels at various concentrations. Biomicrofluidics, 8, 024118 (2014)  

    32. Wang, J., Chen, W., Sun, J., Liu, C., Yin, Q., Zhang, L., Xiangyu, Y., Shi, X., Hu, G. & Jiang, X. A Microfluidic tubing method and its application to controlled synthesis of polymeric nanoparticles. Lab on a Chip, 14, 1673-1677 (2014)  

    31. Yu, W., Qu, H., Hu, G., Zhang, Q., Song, K., Guan, H., Liu, T. & Qin, J. A microfluidic-based multi-shear device for investigating the effects of low fluid-induced stresses on osteoblasts. PLoS ONE, 9, e89966 (2014)   

    30. Wang, J., Ma, J., Ni, Z., Zhang, L. & Hu, G. Effects of access resistance on the resistive-pulse caused by translocating of a nanoparticle through a nanopore. RSC Advances, 4(15), 7601-7610 (2014)  

    29. Kale, A., Patel, S., Qian, S., Hu, G. & Xuan, X. Joule heating effects on reservoirbased dielectrophoresis. Electrophoresis, 35, 721-727 (2014)  

    28. Hu, G., Jiao, B., Shi, X., Valle, R. P., Fan, Q. & Zuo, Y. Y. Physicochemical properties of nanoparticles regulate translocation across pulmonary surfactant monolayer and formation of lipoprotein corona. ACS nano, 7(12), 10525-10533 (2013)   

    27. Kale, A., Patel, S., Hu, G. & Xuan, X. Numercial modeling of Joule heating effects in insulator-based dielectrophoresis microdevices. Electrophoresis, 34, 674-683 (2013)   

    26. Sun, J., Xianyu, Y., Li, M., Liu, W., Zhang, L., Liu, D., Liu, C., Hu, G. & Jiang, X. A microfluidic origami chip for synthesis of functionalized polymeric nanoparticles. Nanoscale, 5(12), 5262-5265 (2013)  

    25. Sun, J., Liu, C., Li, M., Wang, J., Xianyu, Y., Hu, G., & Jiang, X. Size-based hydrodynamic rare tumor cell separation in curved microfluidic channels.  Biomicrofluidics, 7, 011802 (2013)  

    24. Sun, J., Li, M., Liu, C, Zhang Y., Liu, D., Liu, W., Hu, G. & Jiang, X. Double spiral microchannel for label-free tumor cell separation and enrichment. Lab on a Chip, 12, 3952-3960 (2012)  

    23. Zhu, J., Hu, G. & Xuan, X. Electrokinetic particle entry into microchannels. Electrophoresis, 33, 916-922 (2012)  

    22. Zhu, J., Sridharan, S., Hu, G. & Xuan, X. Joule heating effects on electrokinetic focusing and trapping of particles in constriction microchannels. Journal of Micromechanics and Microengineering, 22(7), 075011 (2012) 

    21. Lin, X., Hu, G., Chen, Q., Niu, L., Ostendorf, A. & Sun, H. A light-driven turbine-like micro-rotor and study on its light-to-mechanical power conversion efficiency. Applied Physics Letters, 101(11), 113901 (2012)  

    20. Song, K., Zhang, L. & Hu, G. Modeling of droplet traffic in interconnected microfluidic ladder devices. Electrophoresis, 33, 411-418 (2012)   

    19. Wang, L., Sun, L., Wang, C., Chen, L., Cao, L., Hu, G., Xue, J. & Wang, Y. Nanofluidic pulser based on polymer conical nanopores. Journal of Physical Chemistry C, 115, 22736-22741 (2011)  

    18. Sridharan, S., Zhu, J., Hu, G. & Xuan, X. Joule heating effects on electroosmotic flow in insulator-based dielectrophoresis. Electrophoresis, 32, 2274-2281 (2011)  

    17. Zhu, J., Tzeng, T.-R. J., Hu, G. & Xuan, X. DC dielectrophoretic focusing of particles in a serpentine microchannel. Microfluidics and Nanofluidics, 7, 751-756 (2009)  

    16. Sun, J., Vajandar, S. K., Xu, D., Kang, Y., Hu, G., Li, D. & Li, D. Experimental characterization of electrical current leakage in poly(dimethylsiloxane) microfluidic devices. Microfluidics and Nanofluidics, 6, 589-598 (2009)  

    15. Hu, G. & Li, D. Microfluidic effects of transporting signaling components in cell coculture chips. Microfluidics and Nanofluidics, 6, 99-107 (2009)  

    14. Hu, G., Quaranta, V. & Li, D. Modeling of effects of nutrient gradients on cell proliferation in microfluidic bioreactor. Biotechnology Progress, 23, 1347-1354 (2007).  

    13. Hu, G. & Li, D. Three-dimensional modeling of transport of nutrients for multicellular tumor spheroid culture in a microchannel. Biomedical Microdevices, 9, 315-323 (2007).  

    12. Hu, G. & Li, D. Multiscale phenomena in microfluidics and nanofluidics. Chemical Engineering Science, 62, 3443-3454 (2007).  

    11. Hu, G., Gao, Y. & Li, D. Mo4deling micropatterned antigen-antibody binding kinetics in a microfluidic chip. Biosensors & Bioelectronics, 22, 1403-1409, (2007)  

    10. Xuan, X., Hu, G. & Li, D. Joule heating effects on separation efficiency in capillary zone electrophoresis with an initial voltage ramp. Electrophoresis, 27, 3171-3180 (2006).  

    9. Xiang, Q., Hu, G., Gao, Y. & Li, D. Miniaturized immunoassay microfluidic system with electrokinetic control. Biosensors & Bioelectronics, 21, 2006-2009 (2006)  

    8. Hu, G., Xiang, Q., Fu, R., Xu, B., Venditti, R. & Li, D. Electrokinetically controlled real-time polymerase chain reaction in microchannel using Joule heating effect. Analytica Chimica Acta,  557, 146-151 (2006)  

    7. Hu, G. , Lee, J. S. H. & Li, D. A microfluidic fluorous solid-phase extraction chip for purification of amino acids. Journal of Colloid and Interface Science, 301, 697-702 (2006).  

    6. Hu, G. , Gao, Y., Sherman, P. M. & Li, D. A microfluidic chip for heterogeneous immunoassay using electrokinetical control. Microfluidics and Nanofluidics, 1, 346-355 (2005)  

    5. Gao, Y., Lin, F. Y., Hu, G., Sherman, P. M. & Li, D. Development of a novel electrokinetically driven microfluidic immunoassay for the detection of Helicobacter pylori. Analytica Chimica Acta, 543, 109-116 (2005)   

    4. Gao, Y., Hu, G., Lin, F.Y.H., Sherman, P. M. & Li, D. An electrokinetically-controlled immunoassay for simultaneous detection of multiple microbial antigens. Biomedical Microdevices, 7, 301-312 (2005)  

    3. Igra, O., Hu, G., Falcovitz, J. & Wang, B. Y. Shock wave reflection from a wedge in a dusty gas. International Journal of Multiphase Flow, 30, 1139-1169 (2004)  

    2. Igra, O., Hu, G., Falcovitz, J3. & Heilig, W. Blast waive reflection from wedges. Journal of Fluids Engineering-Transactions of the ASME, 125, 510-519 (2003)  

    1. Igra, O., Wu, X., Hu, G.. & Falcovitz, J. Shock wave propagation into a dust-gas suspension inside a double-bend conduit. Journal of Fluids Engineering-Transactions of the ASME, 124, 483-491 (2002)  

    书籍及章节 

    4. Feng, G., Hu, G., Qiao, R. & Aluru, N. R. 2015. Structure of the electrical double layers: Insight from continuum and atomistic simulations, chapter in Computational Bioengineering. CRC Press. 

    3. 李战华,吴健康,胡国庆,胡国辉. 2012. 微流控芯片中的流体流动. 中国科学出版社. 

    2. Li, D., Hu, G. 2008. Nanoscale biosensors, in Encyclopedia of Micro- and Nanofluidics. Springer.  

    1. Hu, G., Li, D. 2008. Multiscale modeling and numerical simulations, in Encyclopedia of Micro- and Nanofluidics. Springer  

    研究生指导

    中科院优秀导师(2017)

    毕业研究生:宋奎(博士, 2013)、焦豹(博士, 2014)、王俊荣(博士, 2014, 中科院院长优秀奖)、刘超(博士, 2015, 首届中国力学优秀博士论文提名奖、中科院优秀博士博士论文奖、中科院院长优秀奖、博士生国家奖学金)、胡青林(博士,2017)、薛春东(博士,2017,博士生国家奖学金)、贺思远(硕士,2016) 

    在读研究生:白轩、苏敬宏、王铎、黄艺荣

    承担科研项目情况:

  • 1. 自然科学基金重点项目 “基于微纳流控肺器官芯片的纳米颗粒输运研究” 2019-2023

    2. 中科院前沿科学重点项目 2016-2020

    3. 中科院先导B子课题 2016-2020

    4. 自然科学基金 “基于粘弹性效应的颗粒微流控汇聚与分离” 2016-2019

    5. 自然科学基金 “吸入大气细颗粒物与肺表面活性剂、细胞交互作用的力学机制与生物学研究” 2016-2018

    6. 973计划课题 “生物分子在纳通道中的输运及调控” 2011-2015

    7. 自然科学基金 “基于绝缘结构介电泳微流控器件中的电热流动” 2013-2016

    8. 中科院知识创新重要方向  “基于微液滴的微流控系统基础理论研究” 2009-2013

    9. 力学所特聘研究员创新项目  “微纳米流动及输运研究” 2007-2010